AP Endonucleases - Inhibition of APE1

Inhibition of APE1

Known inhibitors of APE1 include 7-nitroindole-2-carboxylic acid (NCA) and lucanthone. Both of these structures possess rings attached to short chains, which appear similar to the deoxyribose sugar ring without a base attached and phosphodiester bond in DNA. Both also contain lots of H-bond acceptors which may interact with the H-bond donors in the active site of APE1, causing these inhibitors to stick in the active site and preventing the enzyme from catalyzing other reactions.