Antidepressant - History

History

Various opiates (via the µ-opioid receptor and κ-opioid receptor) and amphetamines were commonly used as antidepressants until the mid-1950s, when they fell out of favor due to their addictive nature and side-effects. Extracts from the herb St John's Wort have long been used (as a "nerve tonic") to alleviate depression.

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