Anticipation (genetics)
In genetics, anticipation is a phenomenon whereby the symptoms of a genetic disorder become apparent at an earlier age as it is passed on to the next generation. In most cases, an increase of severity of symptoms is also noted. Anticipation is common in trinucleotide repeat disorders such as Huntington's disease and myotonic dystrophy where a dynamic mutation in DNA occurs. All of these diseases have neurological symptoms. Prior to the understanding of the genetic mechanism for anticipation, it was debated whether anticipation was a true biological phenomenon or whether the earlier age of diagnosis was related to heightened awareness of disease symptoms within a family.
Read more about Anticipation (genetics): Trinucleotide Repeats and Expansion, Disease Mechanisms, Examples of Diseases Showing Anticipation
Famous quotes containing the word anticipation:
“Before I had my first child, I never really looked forward in anticipation to the future. As I watched my son grow and learn, I began to imagine the world this generation of children would live in. I thought of the children they would have, and of their children. I felt connected to life both before my time and beyond it. Children are our link to future generations that we will never see.”
—Louise Hart (20th century)