Anti-ganglioside Antibodies - Immunoglobin Isotypes

Immunoglobin Isotypes

IgG. In multiple sclerosis, antibodies to GM1 are dominated by the IgG1, IgG3 and IgG4. Also anti-GM1 IgG has been identified in Guillain-Barré syndrome or chronic inflammatory demyelinating polyradiculoneuropathy. while controlled studies failed to find any significant association with these disease.
IgA. IgA to gangliosides have been observe in Guillain-Barré syndrome.
IgM. IgM antibodies have been detected in early work but their significance in disease is controversial.

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