Longevity Promotion
Knockout of the Agtr1a gene that encodes AT1 results in marked prolongation of the life span of mice by 26% compared to controls. The likely mechanism is reduction of oxidative damage ( especially to mitochondria ) and overexpression of renal prosurvival genes. The ARBs seem to have the same effect.
Read more about this topic: Angiotensin II Receptor Antagonist
Famous quotes containing the words longevity and/or promotion:
“Every thing teaches transition, transference, metamorphosis: therein is human power, in transference, not in creation; & therein is human destiny, not in longevity but in removal. We dive & reappear in new places.”
—Ralph Waldo Emerson (1803–1882)
“Parents can fail to cheer your successes as wildly as you expected, pointing out that you are sharing your Nobel Prize with a couple of other people, or that your Oscar was for supporting actress, not really for a starring role. More subtly, they can cheer your successes too wildly, forcing you into the awkward realization that your achievement of merely graduating or getting the promotion did not warrant the fireworks and brass band.”
—Frank Pittman (20th century)