History
Dr. Heinrich Quincke first described the clinical picture of angioedema in 1882, though there had been some earlier descriptions of the condition.
Sir William Osler remarked in 1888 that some cases may have a hereditary basis; he coined the term "hereditary angio-neurotic edema".
The link with C1 esterase inhibitor deficiency was proved in 1963.
Read more about this topic: Angioedema
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