Pathology
Histologically, they are classified in two variants.
- The classic (or standard) form (95%) has blood filled clefts among bony trabeculae. Osteoid tissue is found in stromal matrix.
- The solid form (5%) shows fibroblastic proliferation, osteoid production and degenerated calcifying fibromyxoid elements.
According to Buraczewski and Dabska, the development of the aneurysmal bone cyst follows three stages.
| Stage | Description |
|---|---|
| Initial phase (I) | Osteolysis without peculiar findings |
| Growth phase (II) |
|
| Stabilization phase (III) | Fully developed radiological pattern |
They can also be associated with a TRE17/USP6 translocation.
Aneurysmal bone cysts may be intraosseous, staying inside of the bone marrow. Or they may be extraosseous, developing on the surface of the bone, and extending into the marrow.
Read more about this topic: Aneurysmal Bone Cyst
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