Androgen Insensitivity Syndrome - Epidemiology

Epidemiology

Estimates for the incidence of androgen insensitivity syndrome are based on a relatively small population size, and thus are known to be imprecise. CAIS is estimated to occur in 1 out of every 20,400 46,XY births. A nationwide survey in The Netherlands based on patients with genetic confirmation of the diagnosis estimates that the minimal incidence of CAIS is 1 in 99,000. The incidence of PAIS is estimated to be 1 in 130,000. Due to its subtle presentation, MAIS is not typically investigated except in the case of male infertility, and thus its true prevalence is unknown.

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