Andrei Smirnov may refer to:
- Andrei Smirnov (actor) (born 1941), Soviet Russian actor and filmmaker
- Andrei Smirnov (footballer born 1969), Soviet and Russian footballer for FC Okean Nakhodka and FC Luch Vladivostok
- Andrei Smirnov (Gundam 00), anime character from the Gundam series
- Andrei Smirnov (ice hockey) (born 1990), professional ice hockey player
- Andrei Smirnov (musician), Russian musician from Terem Quartet
- Andrey Smirnov (swimmer) (born 1957), Soviet Olympic swimmer
- Andrei Viktorovich Smirnov (born 1980), Russian footballer for FC Khimki and FC Vityaz Podolsk
- Andrei Yevgenyevich Smirnov (born 1980), Russian footballer mostly with FC Torpedo Vladimir
- Andrey Andreyevich Smirnov (1905–1982), Soviet ambassador to Austria