Adverse Effects
Common adverse effects include: nausea, dyspepsia, gastrointestinal ulceration/bleeding, raised liver enzymes, diarrhea, constipation, epistaxis, headache, dizziness, priapism, rash, salt and fluid retention, and hypertension. A study from 2010 has shown regular use of NSAIDs was associated with an increase in hearing loss.
Infrequent adverse effects include: esophageal ulceration, heart failure, hyperkalemia, renal impairment, confusion, and bronchospasm. Ibuprofen can exacerbate asthma, sometimes fatally.
Ibuprofen appears to have the lowest incidence of digestive adverse drug reactions of all the nonselective NSAIDs. However, this holds true only at lower doses of ibuprofen, so over-the-counter (OTC) preparations of ibuprofen are, in general, labeled to advise a maximum daily dose of 1,200 mg.
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