Ancestral Reconstruction - Genome Reconstruction

Genome Reconstruction

At chromosomal level, ancestral reconstruction tries to restore the genome rearrangements happened during the evolution. Sometimes it's also called karyotype reconstruction. Chromosome painting is currently the main experimental technique. See refs. Wienberg et al. and Froenicke et al..

Recently, researchers have developed computational methods to reconstruct the ancestral karyotype by taking advantage of comparative genomics. See refs. Murphy et al. and Ma et al..