Classification
The names of the amyloid usually start with the letter "A". Following is a brief description of the more common types of amyloid:
Official abb. |
Amyloid type/Gene | Description | OMIM |
---|---|---|---|
AL | amyloid light chain | AL amyloidosis / multiple myeloma. Contains immunoglobulin light-chains (λ,κ) derived from plasma cells. | 254500 |
AA | SAA | AA amyloidosis | |
Aβ | β amyloid/APP | Found in Alzheimer disease brain lesions. | 605714 |
ATTR | transthyretin | A mutant form of a normal serum protein that is deposited in the genetically determined familial amyloid polyneuropathies. TTR is also deposited in the heart in senile systemic amyloidosis. Also found in Leptomeningeal amyloidosis. | 105210 |
Aβ2M | β2 microglobulin | Not to be confused with Aβ, β2m is a normal serum protein, part of major histocompatibility complex (MHC) Class 1 molecules. Haemodialysis-associated amyloidosis | |
AIAPP | amylin | Found in the pancreas of patients with type 2 diabetes. | |
APrP | prion protein | In prion diseases, misfolded prion proteins deposit in tissues and resemble amyloid proteins. Some examples are Creutzfeldt–Jakob disease (humans), BSE or "mad cow disease" (cattle), and scrapie (sheep and goats). | 123400 |
AGel | GSN | Finnish type amyloidosis | 105120 |
ACys | CST3 | Cerebral amyloid angiopathy, Icelandic-type | 105150 |
AApoA1 | APOA1 | Familial visceral amyloidosis | 105200 |
AFib | FGA | Familial visceral amyloidosis | 105200 |
ALys | LYZ | Familial visceral amyloidosis | 105200 |
? | OSMR | Primary cutaneous amyloidosis | 105250 |
ABri ADan |
ITM2B | Cerebral amyloid angiopathy, British-type Danish-type |
176500 117300 |
APro | prolactin | Prolactinoma | |
AKer | keratoepithelin | Familial corneal amyloidosis | |
AANF | atrial natriuretic factor | Senile amyloid of atria of heart | |
ACal | calcitonin | Medullary carcinoma of the thyroid |
As of 2010, there were 27 human and nine animal fibril proteins classified, along with eight inclusion bodies.
Read more about this topic: Amyloidosis