Amitraz

Amitraz (development code BTS27419) is a non-systemic acaricide and insecticide.1 It has first been synthesized by the Boots Co. in England in 1969. 2 Amitraz has been found to have an insect repellent effect, works as an insecticide and also as a pesticide synergist.3 It's effectiveness is traced back on alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis.4 Therefore it leads to overexcitation and consequently paralysis and death in insects. Because amitraz is less harmful to mammals, amitraz is among many other purposes best known as insecticide against mite- or tick-infestation of dogs.1