AMFR

AMFR

Identifiers Symbols AMFR; GP78; RNF45 External IDs OMIM: 603243 MGI: 1345634 HomoloGene: 888 GeneCards: AMFR Gene EC number 6.3.2.19

Gene Ontology
Molecular function	• ubiquitin-protein ligase activity • receptor activity • protein binding • zinc ion binding • metal ion binding
Cellular component	• nucleus • integral to membrane • integral to endoplasmic reticulum membrane • dendrite • growth cone • neuronal cell body
Biological process	• protein polyubiquitination • ubiquitin-dependent protein catabolic process • cellular component movement • signal transduction • aging • learning or memory • ER-associated protein catabolic process • endoplasmic reticulum unfolded protein response • protein oligomerization
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 267 23802 Ensembl ENSG00000159461 ENSMUSG00000031751 UniProt Q9UKV5 Q9R049 RefSeq (mRNA) NM_001144 NM_011787 RefSeq (protein) NP_001135 NP_035917 Location (UCSC) Chr 16:
56.4 – 56.46 Mb Chr 8:
93.97 – 94.01 Mb PubMed search

Autocrine motility factor receptor, isoform 2 is a protein that in humans is encoded by the AMFR gene.

Autocrine motility factor is a tumor motility-stimulating protein secreted by tumor cells. The protein encoded by this gene is a glycosylated transmembrane protein and a receptor for autocrine motility factor. The receptor, which shows some sequence similarity to tumor protein p53, is localized to the leading and trailing edges of carcinoma cells.