OpenBSD
OpenBSD has supported AMD64 since OpenBSD 3.5, released on 1 May 2004. Complete in-tree implementation of AMD64 support was achieved prior to the hardware's initial release due to AMD's loaning of several machines for the project's hackathon that year. OpenBSD developers have taken to the platform because of its support for the NX bit, which allowed for an easy implementation of the W^X feature.
The code for the AMD64 port of OpenBSD also runs on Intel 64 processors which contains cloned use of the AMD64 extensions, but since Intel left out the page table NX bit in early Intel 64 processors, there is no W^X capability on those Intel CPUs; later Intel 64 processors added the NX bit under the name "XD bit". Symmetric multiprocessing (SMP) works on OpenBSD's AMD64 port, starting with release 3.6 on 1 November 2004.
Read more about this topic: Amd64, Operating System Compatibility and Characteristics, BSD