Amalgam may refer to:
- Amalgam (chemistry), mercury alloy
- Amalgam (dentistry), material of "silver" tooth fillings
- Bonded amalgam, used in dentistry
- Amalgam Comics, publisher
- Amalgam, Gauteng, South Africa
- Amalgam (Marvel Comics), fictional character in the Marvel Universe
- Amalgam, a fictional organization in Full Metal Panic!: The Second Raid
- Maya's Amalgam, comic blog of Maya Zankoul
- Amalgam Digital, an independent record label based in East Boston, Massachusetts