Table of Advanced Disease-modifying Drug (DMD) Candidates
| Target/Approach | Notes (Theoretical) | Candidate Name | Trial Phase | Trial Start Date | Expected End Date | Planned Enrollment | AD population targeted (severity) | AD population targeted (genetic) | Comments |
|---|---|---|---|---|---|---|---|---|---|
| Gamma Secretase Modulator/NSAID | Shifts A-Beta production to shorter and less toxic species | MPC-7869 | Phase III | Feb 2005 | May 2008 | 1,600 | Mild | n/a | 800-patient Trial also underway worldwide. |
| Gamma Secretase Inhibitor | Inhibits Gamma Secretase, believed crucial to pathology | LY451039 | Phase III | March 2008 | March 2012 | 1,500 | Mild-to-Moderate | n/a | smaller trial completed '07, data not out. |
| Antibody to Amyloid-Beta | Mimics Natural Antibody triggered by AN-1792 | aab-001 | Phase III | Dec 2007 | Dec 2010 | 800 | Mild-to-Moderate | Apolipoprotein E4 Carriers only | Identical Trial also underway in Europe |
| Antibody to Amyloid-Beta | Mimics Natural Antibody triggered by AN-1792 | aab-001 | Phase III | Dec 2007 | Dec 2010 | 1,250 | Mild-to-Moderate | Apolipoprotein E4 Non-Carriers only | Identical Trial also underway in Europe |
| Metal-Protein Interaction Attenuation | Primary Targets Copper & Zinc | PBT2 | Phase II (completed) | Dec 2006 | Dec 2007 | 80 | early Alzheimer's disease | n/a | Deemed a Success; Phase III to start |
| Fibrilization of Amyloid-Beta | Prevents/Reverses Fibrilization of A-Beta | AZD-103 | Phase II | Dec 2007 | May 2010 | 340 | Mild-to-Moderate | n/a | Phase I was success |
| Neuroprotection | Neuroprotective Peptide, intra-nasal | AL-108 | Phase II (completed) | Jan 2007 | Jan 2008 | 120 | Mild Cognitive Impairment | n/a | Deemed a Success; Phase III to start |
| Brain Cell Apoptosis Inhibitor | Blocks Mitochondrial Pores | Dimebon | Phase II (completed) | Sept 2006 | Nov 2007 (actual) | 183 | Mild-to-Moderate | n/a | Deemed a Success; Phase III completed but failed |
| Natural Antibodies to A-Beta | human plasma source limits supply | IVIg | Phase II (completed) | Feb 2006 | June 2007 | 24 | Mild-to-Moderate | n/a | Deemed a Success; Phase III to start |
| Vaccine to Amyloid-Beta | Injects modified A-Beta (active vaccine) | acc-001 | Phase II | Nov 2007 | Mar 2012 | 228 | Mild-to-Moderate | n/a | Sequel to famous AN-1792 Vaccine Trial |
| Notes | |||||||||
Read more about this topic: Alzheimer's Disease Clinical Research
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