Toxicity
Being relatively heavy and positively charged, alpha particles tend to have a very short mean free path, and quickly lose kinetic energy within a short distance of their source. This results in several MeV being deposited in a relatively small volume of material. This increases the chance of cellular damage in cases of internal contamination. In general, external alpha radiation is not harmful since alpha particles are effectively shielded by a few centimeters of air, a piece of paper, or the thin layer of dead skin cells that make up the epidermis. Even touching an alpha source is usually not harmful, though many alpha sources also are accompanied by beta-emitting radio daughters, and alpha emission is also accompanied by gamma photon emission. If substances emitting alpha particles are ingested, inhaled, injected or introduced through the skin, then it could result in a measurable dose.
The relative biological effectiveness (RBE) of alpha radiation is higher than that of beta or gamma radiation. RBE quantifies the ability of radiation to cause certain biological effects, notably either cancer or cell-death, for equivalent radiation exposure. The higher value for alpha radiation is generally attributable to the high linear energy transfer (LET) coefficient, which is about one ionization of a chemical bond for every angstrom of travel by the alpha particle. The RBE has been set at the value of 20 for alpha radiation by various government regulations. The RBE is set at 10 for neutron irradiation, and at 1 for beta radiation and ionizing photons.
However, another component of alpha radiation is the recoil of the parent nucleus, termed alpha recoil. Due to the conservation of momentum requiring the parent nucleus to recoil, the effect acts much like the 'kick' of a rifle butt when a bullet goes in the opposite direction. This gives a significant amount of energy to the recoiling nucleus, which also causes ionization damage (see ionizing radiation). The total energy of the recoil nucleus is readily calculable, and is roughly the weight of the alpha (4 u) divided by the weight of the parent (typically about 200 u) times the total energy of the alpha. By some estimates, this might account for most of the internal radiation damage, as the recoil nuclei are typically heavy metals which preferentially collect on the chromosomes. In some studies, this has resulted in a RBE approaching 1,000 instead of the value used in governmental regulations.
The largest natural contributor to public radiation dose is radon, a naturally occurring, radioactive gas found in soil and rock. If the gas is inhaled, some of the radon particles may attach to the inner lining of the lung. These particles continue to decay, emitting alpha particles which can damage cells in the lung tissue. The death of Marie Curie at age 66 from leukemia was probably caused by prolonged exposure to high doses of ionizing radiation, but it is not clear if this was due to alpha radiation or X-rays. Curie worked extensively with radium, which decays into radon, along with other radioactive materials that emit beta and gamma rays. However, Curie also worked with unshielded X-ray tubes during World War I, and analysis of her skeleton during a reburial showed a relatively low level of radioisotope burden.
Russian dissident Alexander Litvinenko's 2006 murder by radiation poisoning is thought to have been carried out with polonium-210, an alpha emitter.
Read more about this topic: Alpha Decay