Contraindications and Precautions
- Alefacept reduces CD4+ T cell counts and may worsen the clinical course of HIV infections. It is therefore contraindicated in patients with HIV infections.
- Pretreatment CD4+ and/or CD8+ cell counts below the accepted lower limit
- History of systemic malignancy
- Caution: Patients at high risk to develop a systemic malignancy
- Known hypersensitivity to alefacept or to any other ingredient of the preparation
- Caution: There is little experience in geriatric patients (65 years of age or older); so far no differences to the younger age group have been noted.
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