Patterns of Differences
By age 3 about 30% of rats have had cancer, whereas by age 85 about 30% of humans have had cancer. Humans, dogs and rabbits get Alzheimer's disease, but rodents do not. Elderly rodents typically die of cancer or kidney disease, but not of cardiovascular disease. In humans, the relative incidence of cancer increases exponentially with age for most cancers, but levels-off or may even decline by age 60–75 (although colon/rectal cancer continues to increase).
Victims of some of the so-called segmental progerias are vulnerable to different sets of diseases. Victims of Werner's syndrome suffer from osteoporosis, cataracts and cardiovascular disease, but not neurodegeneration or Alzheimer's disease. Victim's of Down syndrome suffer type 2 diabetes and Alzheimer's disease, but not high blood pressure, osteoporosis or cataracts. Victims of Bloom syndrome most often die of cancer.
Read more about this topic: Aging-associated Diseases
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