AFN is a three-letter acronym that may refer to:
- Alaska Federation of Natives
- American Forces Network
- Ancestral File Number
- Assembly of First Nations
- AFN Ltd was the company that owned the British car maker Frazer Nash from 1926 to 1957.
- In Finance, Additional Funds Needed
- ISO 4217 currency code of the Afghan afghani
- Nikon AF-N, designation for "new" versions of Nikon AF lenses