Arizona
A 1991 study of α-MSH in 28 "healthy white men" who used a "high-potency sunscreen during the trial" concluded that "Human skin darkens as a response to a synthetic melanotropin given by subcutaneous injection. Skin tanning appears possible without potentially harmful exposure to ultraviolet radiation."
A 1997 pharmacokinetic trial to establish efficacy of peptide administration compared intravenous, oral and subcutaneous routes. The study found that, "subcutaneous administration is an efficacious method of delivering melanotan".
A 1999 clinical dose ranging study in "eight male volunteers with 'tannable' skin types III-IV" given α-MSH (Melanotan-I) determined that an optimal dose for ten daily subcutaneous injections is 0.16 mg/kg per day.
A 2000 study to determine increases of eumelanin expression in seven, "normal volunteers" administered α-MSH concluded that, "the tanning induced by Melanotan in the face and forearm is associated with a significant increase in the eumelanin content of the human skin."
Three 2004 Phase I clinical trials sought to establish the safety of α-MSH therapy combined with UV-B light or sunlight exposure. The researchers determined, "Melanotan-1 can be safely combined with UV-B light or sunlight and appears to act synergistically in the tanning response to light." This trial was funded by the National Cancer Institute.
Read more about this topic: Afamelanotide, Human Pigmentation Clinical Trials
Famous quotes containing the word arizona:
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