ADH1B

ADH1B

Identifiers Symbols ADH1B; ADH2 External IDs OMIM: 103720 HomoloGene: 88336 ChEMBL: 3284 GeneCards: ADH1B Gene EC number 1.1.1.1

Gene Ontology
Molecular function	• nucleotide binding • alcohol dehydrogenase activity, zinc-dependent • zinc ion binding • metal ion binding
Cellular component	• cytosol
Biological process	• ethanol oxidation • xenobiotic metabolic process • small molecule metabolic process
Sources: Amigo / QuickGO

Orthologs Species Human Mouse Entrez 125 n/a Ensembl ENSG00000196616 n/a UniProt P00325 n/a RefSeq (mRNA) NM_000668 n/a RefSeq (protein) NP_000659 n/a Location (UCSC) Chr 4:
100.23 – 100.24 Mb n/a PubMed search n/a

Alcohol dehydrogenase 1B is an enzyme that in humans is encoded by the ADH1B gene.

The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster.

The human gene is located on chromosome 4 in 4q22.

Previously ADH1B was called ADH2. There are more genes in the family of alcohol and aldehyde dehydrogenase genes. These genes are now referred to as ADH1A, ADH1C, and ADH4, ADH5, ADH6 and ADH7.