ACV may refer to:
- Aciclovir, an antiviral drug
- Actual cash value, money equal to the cost of replacing lost, stolen, or damaged property after depreciation
- Allegheny-Clarion Valley School District, a public school district in Clarion County, Pennsylvania, United States
- Apple cider vinegar, a common vinegar available to consumers, popularly used in alternative medicine
- Armored combat vehicle, as in
- ACV-S, a Turkish military vehicle
- ACV-300, a family of Turkish military vehicles
- All commodity volume, the total annual sales volume of retailers that can be aggregated from individual store-level up to larger Geographical sets
- Asianet Cable Vision, a company that provide services on cable TV, broadband internet connections, web hosting and VoIP services in Kerala, India
- Asser Christelijke Voetbalvereniging (English: Assen Christian Football Club), a Dutch amateur football club
- Armored Core V, a 3D mecha-based video game for the PlayStation 3 and Xbox 360
- Associated Commercial Vehicles, a former vehicle manufacturer of the United Kingdom, acquired by Leyland Motors Ltd
- Automatic control valve, a type of hydraulic or pneumatic valve
- Confederation of Christian Trade Unions (Dutch: Algemeen Christelijk Vakverbond), a Belgian trade union
- Hovercraft, also known as "air cushion vehicle", a type of vehicle supported by high pressure air
- δ-(L-α-amino-adipate)-L-cysteine-D-valine, the biological precursor of penicillin
ACV is also used as an official code or symbol
- IATA code and FAA LID: Arcata-Eureka Airport, an airport in McKinleyville, California, United States
- ICAO code: Air Charter Service, United Kingdom