Acute Myeloid Dendritic Cell Leukemia - Molecular Findings, Cytochemistry, and Molecular Genetics

Molecular Findings, Cytochemistry, and Molecular Genetics

The WHO criterion for diagnosis of AML is that myeloid precursors or blasts must represent at least 20% of the cellularity of bone marrow. In the case of acute myeloid dendritic cell leukemia, the blast cells are positive for markers of dendritic cells or monocytes. The markers include CD11c, CD80, CD83, CD86, and major histocompatibility complex class II antigens. The neoplastic dendritic cells are negative for the enzymes myeloperoxidase and esterase. The cells elaborate many cytokines including IL-6 and IL-12.