Cytogenetics
Cytogenetic translocations associated with specific molecular genetic abnormalities in ALL
| Cytogenetic translocation | Molecular genetic abnormality | % |
|---|---|---|
| cryptic t(12;21) | TEL-AML1 fusion | 25.4% |
| t(1;19)(q23;p13) | E2A-PBX (PBX1) fusion | 4.8% |
| t(9;22)(q34;q11) | BCR-ABL fusion(P185) | 1.6% |
| t(4;11)(q21;q23) | MLL-AF4 fusion | 1.6% |
| t(8;14)(q24;q32) | IGH-MYC fusion | |
| t(11;14)(p13;q11) | TCR-RBTN2 fusion |
12;21 is the most common translocation and portends a good prognosis. 4;11 is the most common in children under 12 months and portends a poor prognosis.
Read more about this topic: Acute Lymphoblastic Leukemia