2006 U.S. Formula Change
The original formula for Actifed contained pseudoephedrine hydrochloride 60 mg as the nasal decongestant and triprolidine hydrochloride 2.5 mg as the antihistamine. However, in response to widespread laws requiring products containing pseudoephedrine to be kept behind the pharmacy counter, Pfizer changed Actifed's U.S. formula in late 2006 to contain chlorpheniramine maleate 4 mg as the antihistamine and phenylephrine HCl 10 mg as the nasal decongestant. Many users of the old formula have complained that the new formula is not as effective at relieving their symptoms. Other brands available behind the counter that use the old formula include Genac and Aprodine. The American pharmacy chain Walgreens produces a house-brand version of Actifed, Wal-Act, which uses the original pseudoephedrine/triprolidine formula.
In the UK, Germany, and Thailand (Before January 2012), the product is available Over-the-counter as a pack of 12 tablets produced by McNeil. Each tablet contains Triprolidine hydrochloride 2.5 mg and Pseudoephedrine hydrochloride 60 mg.
In Germany, the product is marketed under the registered trademark Rhino PRONT.
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