Acromegaly - Signs and Symptoms

Signs and Symptoms

Features that result from high level of GH or expanding tumor include:

• Soft tissue swelling visibly resulting in enlargement of the hands, feet, nose, lips and ears, and a general thickening of the skin.
• Soft tissue swelling of internal organs, notably the heart with attendant weakening of its muscularity, and the kidneys, also the vocal cords resulting in a characteristic thick, deep voice and slowing of speech
• Generalized expansion of the skull at the fontanelle
• Pronounced brow protrusion, often with ocular distension
• Pronounced lower jaw protrusion with attendant macroglossia (enlargement of the tongue) and teeth gapping
• Hypertrichosis, hyperpigmentation, and hyperhidrosis may occur in these patients.
• Acrochordon (skin tags)
• Carpal tunnel syndrome