Acquired Hemolytic Anemia - Immune

Immune

Immune mediated hemolytic anemia (direct Coombs test is positive)

  • Autoimmune hemolytic anemia
    • Warm antibody autoimmune hemolytic anemia
      • Idiopathic
      • Systemic lupus erythematosus (SLE)
      • Evans' syndrome (antiplatelet antibodies and hemolytic antibodies)
    • Cold antibody autoimmune hemolytic anemia
      • Idiopathic cold hemagglutinin syndrome
      • Infectious mononucleosis and mycoplasma (atypical) pneumonia
      • Paroxysmal cold hemoglobinuria (rare)
  • Alloimmune hemolytic anemia
    • Hemolytic disease of the newborn (HDN)
      • Rh disease (Rh D)
      • ABO hemolytic disease of the newborn
      • Anti-Kell hemolytic disease of the newborn
      • Rhesus c hemolytic disease of the newborn
      • Rhesus E hemolytic disease of the newborn
      • Other blood group incompatibility (RhC, Rhe, Kidd, Duffy, MN, P and others)
    • Alloimmune hemolytic blood transfusion reactions (i.e. from a non-compatible blood type)
  • Drug induced immune mediated hemolytic anemia
    • Penicillin (high dose)
    • Methyldopa

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