Detection Limits
A multidimensional population translation experiment was utilized to determine the detection limits of an ARS device according to AAPS PharmSciTech 2006; 7 (1) Article 25 (http://www.aapspharmscitech.org). Populations with small multidimensional separation, in this case aspirin and ibuprofen, were used to determine that tablets with a 0.08 mm difference in thickness, 0.0046 g mass difference, and a difference in density of 0.01658 g/mL were not separable by ARS. Using vitamin C and acetaminophen for the largest multidimensional separation, tablets with a thickness difference of 0.27 mm, 0.0756 g mass difference, and 0.01157 g/mL density difference in density were inseparable. Experimentally the dynamic range of ARS is a factor of ten.
Read more about this topic: Acoustic Resonance Spectroscopy
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