Participation in Wood-Ljungdahl Pathway
Acetyl—CoA synthetase also participates in the Wood-Ljungdahl Pathway, which fixes anaerobic CO2. The Wood-Ljungdahl Pathway consists of an eastern branch, which all organisms use in one-carbon metabolism, and a western branch, which only anaerobes use for fixing carbon dioxide and carbon monoxide. To be specific, ACS combines carbon monoxide and a methyl group to produce acetyl-CoA at a nickel-containing active site.
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