ACE Inhibitors Drug Design
The discovery of an orally inactive peptide from snake venom established the important role of angiotensin converting enzyme (ACE) inhibitors in regulating blood pressure. This led to the development of Captopril, the first ACE inhibitor. When the adverse effects of Captopril became apparent new derivates were designed. Then after the discovery of two active sites of ACE: N-domain and C-domain, the development of domain specific ACE inhibitors began.
Read more about ACE Inhibitors Drug Design: Development of First Generation ACE Inhibitors, Discovery of 2 Active Sites: C-domain and N-domain, Drug Design of Keto-ACE and Its Ketomethylene Derivatives, Drug Design of Silanediol, Phosphinic Peptides
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