ABO (gene)

ABO (gene)

Identifiers Symbols ABO; A3GALNT; A3GALT1; GTB; NAGAT External IDs OMIM: 110300 MGI: 2135738 HomoloGene: 69306 GeneCards: ABO Gene EC number 2.4.1.40 2.4.1.37, 2.4.1.40

Gene Ontology
Molecular function	• glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity • fucosylgalactoside 3-alpha-galactosyltransferase activity • metal ion binding
Cellular component	• extracellular region • integral to Golgi membrane • Golgi cisterna membrane
Biological process	• protein glycosylation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 28 80908 Ensembl ENSG00000175164 ENSMUSG00000015787 UniProt P16442 P38649 RefSeq (mRNA) NM_020469 NM_030718 RefSeq (protein) NP_065202 NP_109643 Location (UCSC) Chr 9:
136.13 – 136.15 Mb Chr 2:
26.84 – 26.86 Mb PubMed search

Histo-blood group ABO system transferase is an enzyme with glycosyltransferase activity which in humans is encoded by the ABO gene.

It determines the ABO blood group of an individual by modifying the oligosaccharides on cell surface glycoproteins. Variations in the sequence of the protein between individuals determine the type of modification and the blood group.