Computers
- ABC (computer virus)
- ABC (programming language), a programming language and environment
- ABC (stream cipher), a stream cipher algorithm
- ABC (Yet Another BitTorrent Client), a BitTorrent client
- ABC, a line of computers by Dataindustrier AB
- ABC notation, a language for music notation
- Abstract base class, a programming language concept
- Acorn Business Computer, a series of microcomputers announced at the end of 1983 by the British company Acorn Computers
- .abc, ActionScript Byte Code files; see Comparison of application virtual machines
- Alcatel Business Communications, a telecommunications protocol
- Artificial Bee Colony Algorithm, a search algorithm
- Atanasoff–Berry Computer, an early electronic digital computer
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