Cast
- Garrison Keillor (the show's creator) as himself
- Meryl Streep as Yolanda Johnson (Streep later appeared on the actual radio show, reprising this role)
- Lily Tomlin as Rhonda Johnson, sister of Yolanda. They are from Oshkosh, Wisconsin, the last two members of a bygone family country music act
- Lindsay Lohan as Lola Johnson, who writes about suicide. She is Yolanda's daughter
- Woody Harrelson as Dusty, a singing cowboy
- John C. Reilly as Lefty, a singing cowboy
- Tommy Lee Jones as the Axeman, a businessman from Texas who has come to shut down the show
- Kevin Kline as Keillor's radio character Guy Noir, a film noir P.I. repurposed as the program's security director
- Virginia Madsen as the Dangerous Woman, "Asphodel", who may or may not be the Angel of Death (Asphodel is a flower, referenced in the poem "Demeter And Persephone" by Alfred Lord Tennyson and associated with death and Hades in Greek mythology)
- L. Q. Jones as Chuck Akers
- Tim Russell as the stage manager
- Maya Rudolph as the assistant stage manager
- Robin and Linda Williams as themselves (singing duo)
- Tom Keith as the Sound-Effects Guy
- Sue Scott as the Make-Up Artist
Read more about this topic: A Prairie Home Companion (film)
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