Pharmacology
DOI is a 5-HT2A, 5-HT2B, and 5-HT2C receptor partial agonist. Its psychedelic effects are mediated by its agonistic properties at the 5-HT2A receptor. Due to its selectivity, DOI is often used in scientific research when studying the 5-HT2 receptor subfamily.
The solubility of DOI hydrochloride in H2O is 10 mg/ml, and in ethanol 2 mg/ml.
DOI has also recently been shown to be an extremely potent inhibitor of tumor necrosis factor-alpha, an inflammatory mediator which is an important target for current research into degenerative conditions such as arthritis and Alzheimer's disease, where the disease process involves tissue damage through chronic inflammation. This could make DOI and other 5-HT2A agonists an entirely new area for development of novel treatments for these conditions.
Read more about this topic: 2,5-Dimethoxy-4-iodoamphetamine