Diseases Related To 2,3-BPG
- Hyperthyroidism
A 2004 study checked the effects of thyroid hormone on 2,3-BPG levels. The result was that the hyperthyroidism modulates in vivo 2,3-BPG content in erythrocytes by changes in the expression of phosphoglycerate mutase (PGM) and 2,3-BPG synthase. This result shows that the increase in the 2,3-BPG content of erythrocytes observed in hyperthyroidism doesn’t depend on any variation in the rate of circulating hemoglobin, but seems to be a direct consequence of the stimulating effect of thyroid hormones on erythrocyte glycolytic activity.
- Iron deficiency anaemia
This illness is characterized by a lack of iron, and as 2,3-BPG needs this chemical element to be synthesized, BPG concentration decreases and hemoglobin binds tightly to oxygen. As a result, oxygen release to tissue is reduced.
- Chronic respiratory disease with hypoxia
Recently, scientists have found similarities between low amounts of 2,3-BPG with the occurrence of high altitude pulmonary edema at high altitudes.
| n | Hb (g/dl) | 2,3-BPG (mM) | ||
|---|---|---|---|---|
| 1 | Normality | 120 | 14.2 ± 1.6 | 4.54 ± 0.57 |
| 2 | Hyperthyroidism | 35 | 13.7 ± 1.4 | 5.66 ± 0.69 |
| 3 | Iron deficiency anaemia | 40 | 10.0 ± 1.7 | 5.79 ± 1.02 |
| 4 | Chronic respiratory disease with hypoxia | 47 | 16.4 ± 2.2 | 5.29 ± 1.13 |
Read more about this topic: 2,3-Bisphosphoglyceric Acid
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