Diseases Related To 2,3-BPG
- Hyperthyroidism
A 2004 study checked the effects of thyroid hormone on 2,3-BPG levels. The result was that the hyperthyroidism modulates in vivo 2,3-BPG content in erythrocytes by changes in the expression of phosphoglycerate mutase (PGM) and 2,3-BPG synthase. This result shows that the increase in the 2,3-BPG content of erythrocytes observed in hyperthyroidism doesn’t depend on any variation in the rate of circulating hemoglobin, but seems to be a direct consequence of the stimulating effect of thyroid hormones on erythrocyte glycolytic activity.
- Iron deficiency anaemia
This illness is characterized by a lack of iron, and as 2,3-BPG needs this chemical element to be synthesized, BPG concentration decreases and hemoglobin binds tightly to oxygen. As a result, oxygen release to tissue is reduced.
- Chronic respiratory disease with hypoxia
Recently, scientists have found similarities between low amounts of 2,3-BPG with the occurrence of high altitude pulmonary edema at high altitudes.
| n | Hb (g/dl) | 2,3-BPG (mM) | ||
|---|---|---|---|---|
| 1 | Normality | 120 | 14.2 ± 1.6 | 4.54 ± 0.57 |
| 2 | Hyperthyroidism | 35 | 13.7 ± 1.4 | 5.66 ± 0.69 |
| 3 | Iron deficiency anaemia | 40 | 10.0 ± 1.7 | 5.79 ± 1.02 |
| 4 | Chronic respiratory disease with hypoxia | 47 | 16.4 ± 2.2 | 5.29 ± 1.13 |
Read more about this topic: 2,3-Bisphosphoglyceric Acid
Famous quotes containing the words diseases and/or related:
“Arrogance, pedantry, and dogmatism ... the occupational diseases of those who spend their lives directing the intellects of the young.”
—Henry S. Canby (1878–1961)
“Women stand related to beautiful nature around us, and the enamoured youth mixes their form with moon and stars, with woods and waters, and the pomp of summer. They heal us of awkwardness by their words and looks. We observe their intellectual influence on the most serious student. They refine and clear his mind: teach him to put a pleasing method into what is dry and difficult.”
—Ralph Waldo Emerson (1803–1882)