The 2008 American League Division Series (ALDS), the first round of the 2008 American League playoffs, consisted of two best-of-five series. They were:
- (1) Los Angeles Angels of Anaheim (Western Division champions, 100–62) vs. (4) Boston Red Sox (Wild Card qualifier, 95–67): Red Sox win series, 3–1.
- (2) Tampa Bay Rays (Eastern Division champions, 97–65) vs. (3) Chicago White Sox (Central Division champions, 89–74): Rays win series, 3–1.
Since the Twins and the White Sox completed the regular season with identical records (88–74), the two teams played against each other in a one-game playoff. The White Sox defeated the Twins, 1–0, and thus became the AL Central champions.
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