Offseason
- November 18, 2005: Xavier Nady was traded by the San Diego Padres to the New York Mets for Mike Cameron.
- December 2, 2005: Pete Laforest was selected off waivers by the San Diego Padres from the Tampa Bay Devil Rays.
- December 5, 2005: Brian Giles was signed as a Free Agent with the San Diego Padres.
- December 7, 2005: Dewon Brazelton was traded by the Tampa Bay Devil Rays to the San Diego Padres for Sean Burroughs.
- December 22, 2005: Mark Bellhorn was signed as a Free Agent with the San Diego Padres.
- January 4, 2006: Adam Eaton, Akinori Otsuka, and Billy Killian were traded to the Texas Rangers in exchange for Adrian Gonzalez, Chris Young, and Terrmel Sledge.
- January 12, 2006: Alan Embree was signed as a Free Agent with the San Diego Padres.
- February 3, 2006: Mike Piazza signed as a Free Agent with the San Diego Padres.
- May 1, 2006: Doug Mirabelli was traded to the Boston Red Sox in exchange for Josh Bard and Cla Meredith.
Read more about this topic: 2006 San Diego Padres Season