Schedule
| Week | Date | Opponent | Result | Record | Game Site | NFL Recap |
|---|---|---|---|---|---|---|
| 1 | September 10, 2006 | at New York Giants | W 26–21 | 1–0 | Giants Stadium | Recap |
| 2 | September 17, 2006 | Houston Texans | W 43–24 | 2–0 | RCA Dome | Recap |
| 3 | September 24, 2006 | Jacksonville Jaguars | W 21–14 | 3–0 | RCA Dome | Recap |
| 4 | October 1, 2006 | at New York Jets | W 31–28 | 4–0 | Giants Stadium | Recap |
| 5 | October 8, 2006 | Tennessee Titans | W 14–13 | 5–0 | RCA Dome | Recap |
| 6 | Bye | |||||
| 7 | October 22, 2006 | Washington Redskins | W 36–22 | 6–0 | RCA Dome | Recap |
| 8 | October 29, 2006 | at Denver Broncos | W 34–31 | 7–0 | Invesco Field | Recap |
| 9 | November 5, 2006 | at New England Patriots | W 27–20 | 8–0 | Gillette Stadium | Recap |
| 10 | November 12, 2006 | Buffalo Bills | W 17–16 | 9–0 | RCA Dome | Recap |
| 11 | November 19, 2006 | at Dallas Cowboys | L 14–21 | 9–1 | Texas Stadium | Recap |
| 12 | November 26, 2006 | Philadelphia Eagles | W 45–21 | 10–1 | RCA Dome | Recap |
| 13 | December 3, 2006 | at Tennessee Titans | L 17–20 | 10–2 | LP Field | Recap |
| 14 | December 10, 2006 | at Jacksonville Jaguars | L 17–44 | 10–3 | Alltel Stadium | Recap |
| 15 | December 18, 2006 | Cincinnati Bengals | W 34–16 | 11–3 | RCA Dome | Recap |
| 16 | December 24, 2006 | at Houston Texans | L 24–27 | 11–4 | Reliant Stadium | Recap |
| 17 | December 31, 2006 | Miami Dolphins | W 27–22 | 12–4 | RCA Dome | Recap |
Read more about this topic: 2006 Indianapolis Colts Season