Schedule
| Week | Date | Opponent | Result | Attendance |
|---|---|---|---|---|
| 1 | September 10, 2006 | Seattle Seahawks | L 9-6 |
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| 2 | September 17, 2006 | at Chicago Bears | L 34-7 |
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| 3 | September 24, 2006 | Green Bay Packers | L 31-24 |
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| 4 | October 1, 2006 | at St. Louis Rams | L 41-34 |
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| 5 | October 8, 2006 | at Minnesota Vikings | L 26-17 |
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| 6 | October 15, 2006 | Buffalo Bills | W 20-17 |
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| 7 | October 22, 2006 | at New York Jets | L 31-24 |
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| 8 | Bye | |||
| 9 | November 5, 2006 | Atlanta Falcons | W 30-14 |
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| 10 | November 12, 2006 | San Francisco 49ers | L 17-10 |
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| 11 | November 19, 2006 | at Arizona Cardinals | L 17-10 |
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| 12 | November 23, 2006 | Miami Dolphins | L 27-10 |
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| 13 | December 3, 2006 | at New England Patriots | L 28-21 |
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| 14 | December 10, 2006 | Minnesota Vikings | L 30-20 |
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| 15 | December 17, 2006 | at Green Bay Packers | L 17-9 |
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| 16 | December 24, 2006 | Chicago Bears | L 26-21 |
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| 17 | December 31, 2006 | at Dallas Cowboys | W 39-31 |
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Read more about this topic: 2006 Detroit Lions Season