Schedule
| Week | Date | Opponent | Result | Attendance |
|---|---|---|---|---|
| 1 | September 10, 2006 | at New England Patriots | L 19–17 |
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| 2 | September 17, 2006 | at Miami Dolphins | W 16–6 |
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| 3 | September 24, 2006 | New York Jets | L 28–20 |
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| 4 | October 1, 2006 | Minnesota Vikings | W 17–12 |
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| 5 | October 8, 2006 | at Chicago Bears | L 40–7 |
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| 6 | October 15, 2006 | at Detroit Lions | L 20–17 |
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| 7 | October 22, 2006 | New England Patriots | L 28–6 |
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| 8 | Bye | |||
| 9 | November 5, 2006 | Green Bay Packers | W 24–10 |
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| 10 | November 12, 2006 | at Indianapolis Colts | L 17–16 |
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| 11 | November 19, 2006 | at Houston Texans | W 24–21 |
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| 12 | November 26, 2006 | Jacksonville Jaguars | W 27–24 |
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| 13 | December 3, 2006 | San Diego Chargers | L 24–21 |
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| 14 | December 10, 2006 | at New York Jets | W 31–13 |
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| 15 | December 17, 2006 | Miami Dolphins | W 21–0 |
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| 16 | December 24, 2006 | Tennessee Titans | L 30–29 |
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| 17 | December 31, 2006 | at Baltimore Ravens | L 19–7 |
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The Bills season opener at New England marked the first time the Bills did not open at home since 1999. The Bills played all of their games on Sunday afternoons this season, joining the Detroit Lions, Houston Texans, and Tennessee Titans as teams without an appearance on primetime in 2006.
Read more about this topic: 2006 Buffalo Bills Season