The 2006 American League Division Series (ALDS), the opening round of the 2006 American League playoffs, began on Tuesday, October 3, and ended on Saturday, October 7, with the champions of the three AL divisions—along with a "wild card" team—participating in two best-of-five series. They were:
- (1) New York Yankees (Eastern Division champions, 97–65) vs. (4) Detroit Tigers (Wild Card, 95–67); Tigers win series, 3–1.
- (2) Minnesota Twins (Central Division champions, 96–66) vs. (3) Oakland Athletics (Western Division champions, 93–69); Athletics win series, 3–0.
The higher seed (in parentheses) had the home field advantage, which was determined by playing record.
The Athletics and Tigers met in the AL Championship Series, where a Detroit sweep made the Tigers the American League champions. The Tigers then faced the St. Louis Cardinals in the 2006 World Series, and lost, four games to one, despite having home-field advantage.
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