Schedule
| Date | Time | Opponent# | Rank# | Site | TV | Result | Attendance | |
|---|---|---|---|---|---|---|---|---|
| September 5 | 3:30 PM | Kentucky* | Papa John's Cardinal Stadium • Louisville, KY (Governor's Cup) | ESPN | W 28–0 | 42,681 | ||
| September 11 | 1:00 PM | at Army | Michie Stadium • West Point, NY | WDRB | W 52–21 | 28,130 | ||
| September 25 | 1:30 PM | at North Carolina* | #24 | Kenan Memorial Stadium • Chapel Hill, NC | ESPN+ | W 34–0 | 49,000 | |
| October 2 | 3:00 PM | East Carolina | #22 | Papa John's Cardinal Stadium • Louisville, KY | ESPN+ | W 59–7 | 40,220 | |
| October 14 | 7:30 PM | at #3 Miami (FL)* | #17 | Orange Bowl • Miami, FL | ESPN | L 38–41 | 63,715 | |
| October 22 | 8:00 PM | USF | #17 | Papa John's Cardinal Stadium • Louisville, KY | ESPN | W 41–9 | 42,032 | |
| November 4 | 7:30 PM | at Memphis | #14 | Liberty Bowl • Memphis, TN | ESPN | W 56–49 | 52,384 | |
| November 10 | 7:30 PM | TCU | #12 | Papa John's Cardinal Stadium • Louisville, KY | ESPN2 | W 55–28 | 40,107 | |
| November 20 | 5:00 PM | at Houston | #10 | Robertson Stadium • Houston, TX | ESPN+ | W 65–27 | 20,176 | |
| November 27 | 2:30 PM | Cincinnati | #9 | Papa John's Cardinal Stadium • Louisville, KY (The Keg of Nails) | ESPN2 | W 70–7 | 37,617 | |
| December 4 | 2:30 PM | at Tulane | #8 | Louisiana Superdome • New Orleans, LA | ESPN+ | W 55–7 | 22,169 | |
| December 31 | 3:30 PM | vs. #10 Boise State* | #8 | Liberty Bowl • Memphis, TN (Liberty Bowl) | ESPN | W 44–40 | 58,355 | |
Read more about this topic: 2004 Louisville Cardinals Football Team