2-hydroxy-3-oxopropionate Reductase

In enzymology, a 2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60) is an enzyme that catalyzes the chemical reaction

(R)-glycerate + NAD(P)+ 2-hydroxy-3-oxopropanoate + NAD(P)H + H+

The 3 substrates of this enzyme are (R)-glycerate, NAD+, and NADP+, whereas its 4 products are 2-hydroxy-3-oxopropanoate, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-glycerate:NAD(P)+ oxidoreductase. This enzyme is also called tartronate semialdehyde reductase. This enzyme participates in glyoxylate and dicarboxylate metabolism.