Round of 16
First leg matches were played between April 5 and April 6. Second leg matches were played on April 12 and April 13.
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| Atlético Nacional | 3-2 | Racing | 2-0 | 1-2 |
| Millonarios | 3-3 (4-3 pk) | Bolivar | 0-1 | 3-2 |
| Cobreloa | 1-0 | Deportivo Quito | 0-0 | 1-0 |
| Danubio | 3-1 | Nacional | 3-1 | 0-0 |
| Peñarol | 3-8 | Internacional | 2-6 | 1-2 |
| Bahia | 3-2 | Universitario | 1-1 | 2-1 |
| Deportivo Táchira | 3-3 (2-3 pk) | Sol de América | 0-3 | 3-0 |
| Boca Juniors | 5-5 (6-7 pk) | Olimpia | 0-2 | 5-3 |
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