Second Round
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| Djoliba AC | 1-2 | Hearts of Oak | 1-1 | 0-1 |
| Etoile du Congo | 1-1 (3-1 pen) | Hafia FC | 0-1 | 1-0 |
| Simba SC | 2-5 | Union Douala | 2-4 | 0-1 |
| Silures | 0-4 | Canon Yaoundé | 0-1 | 0-3 |
| AC Semassi | 1-2 | ASF Police | 1-1 | 0-1 |
| Stella Club d'Adjamé | 5-5 | MP Algiers | 4-2 | 1-3 |
| Bendel Insurance | 4-4 | Gor Mahia | 1-2 | 3-2 |
| AS Bilima | 4-1 | Fortior Mahajanga | 3-0 | 1-1 |
Read more about this topic: 1980 African Cup Of Champions Clubs
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