17Beta Hydroxysteroid Dehydrogenase

17Beta Hydroxysteroid Dehydrogenase

17β-Hydroxysteroid dehydrogenases (17β-HSD), also known as 17-ketosteroid oxidoreductases, HSD17B or simply as 17-ketosteroid reductases (17-KSR), are a group of alcohol oxidoreductases which catalyse the dehydrogenation of 17-hydroxysteroids in steroidogenesis. This includes interconversion of DHEA and androstenediol, androstenedione and testosterone, and estrone and estradiol, respectively.

Note that the major reactions catalysed by 17β-HSD (e.g., the conversion of androstenedione to testosterone) are in fact hydrogenation (reduction) rather than dehydrogenation (oxidation) reactions.